May 27, 1896, 255 killed
With over a mile of whipping winds, the tornado hit about 6 miles (9.7 km) west of the Eads Bridge in St. Louis and swept east over highly populated areas. Lafayette Park, along with houses, industrial areas, hospitals and churches, was destroyed. The tornado then crossed the Mississippi River into Illinois and continued to cause destruction.
Next Tupelo, Miss., 1936