April 24, 1908, 143 killed
What started in Louisiana moved east and kept tearing apart towns on its way into Mississippi. The worst hit area at the start of the devastation was in Amite, La., where the two-mile-wide path killed 29. Things kept getting deadlier as 55 people were killed in Purvis, Miss., and most of the town was wiped out. The tornado ran through a rail yard and tossed boxcars—where workers hid—up to 150 feet.
Next Joplin, Mo., 2011